Lapacho – 30 ml

Lapacho Di Leo - 30 ml

Ingredients:

Water, Alcohol, LAPACHO (Tabebuia avellanedae Lorents) bark

Keyword:

Bactericidal, bacteriostatic, virucidal, antiparasitic, fungicidal, anti-inflammatory, purifying, immunostimulant, astringent,

antidiarrheal, vulnerary, diuretic, mild expectorant, sedative, mild febrifuge, hypotensive, mild general tonic, cardiotonic.

Characteristics:

Typical tree of South America (Brazil and Argentina). The Indians already made extensive use of this plant to prevent and treat various diseases and, precisely because of its many properties, they defined it as the tree of life or divine tree. The Tabebuia avellanedae typical of the more internal areas of Mexico, Brazil and Argentina is of great interest for therapeutic use.

The bark of the Lapacho (phloem) is the one that gives the best therapeutic results. The processing of the Di Leo srl Herbal Laboratory allows us to isolate all the active ingredients, recovering 20 mineral salts that are not water-soluble in nature.

Lapacho has a purifying action and above all is able to increase or restore the immune defenses in immunodeficient or immunosuppressed subjects, even following long cortisone and/or antibiotic treatments and in particular conditions such as diabetes, blood disorders caused by cellular immunity deficiency and leukocyte defenses.

These subjects are at risk of candidiasis, due to fungi which, under normal conditions, are common hosts of humans, but which, occasionally, can become pathogenic causing infections of the respiratory, genital, skin, intestinal systems or generalized infections.

Directions:

Arthritis, wounds and ulcers, asthma and bronchitis, general pain, heart weakness, gastritis, gastric ulcer, infections of the mouth, nose and throat, parasitic infections, bacterial infections with staphylococci, streptococci, viral infections: flu, colds, herpes, conditions skin, eczema, acne, furunculosis, psoriasis, gastrointestinal tract disorders, colitis, inflammation of the mucous membranes, dysentery, peptic ulcers, disorders of the urogenital system, cystitis, urethritis, prostatitis, vaginitis, leukorrhea, inflammation of the uterine cervix.

Dosage:

21 drops in water, 3 times a day, before meals for at least 6 months. for the next 6 months: 14 drops 3 times a day.

Synergistic protocols:

FLU: Immuno-Herb® (S48 Echinacea)30 drops in water 3 times a day before meals. Reno-Dren®: 1 teaspoon (5 ml) in a glass of water 2 times a day 10 minutes before meals. C 2000®: 1 tablet per day to dissolve slowly in the mouth, or chew, after meals. THROAT INFLAMMATION: Immuno-Herb® (S48 Echinacea) 30 drops in water 3 times a day 10 minutes before meals, Propol Mix 1®* or Propol Mix 2®: 30 drops in water 3 times a day after meals, Drain -Herb® (S65 Solidago): 30 drops in water 2 times a day 10 minutes before meals. *Contraindicated in case of ulcer, gastritis, arterial hypertension and insomnia.

ACTIVE PRINCIPLES

18 quinones: naphthaquinones (n-factors) - anthraquinones (a-factors) - Lapacholo - Lapachone - xyloidone, quercetin, lapachenol, carnosol, indoles, coenzyme q, alkaloids (thecomine), hydroxybenzoic acids, steroid saponins and tannic acid vanillin, acid vanillic acid (4-hydroxymethoxybenzoic acid), veratric acid (3,4-dimethoxybenzoic acid), verataldehyde. Constituents that have been shown to have a bactericidal and fungicidal action. Verataldehyde has a weak stimulating activity in the phagocytosis of granulocytes and a high stimulating activity in the proliferation of lymphocytes. In 1884 E.Paterno isolated the active constituent Lapacholo: it is a quinone that shows antiviral activity against HERPES SIMPLEX types I and II and several influenza viruses. Lapacho has proven useful against stress-induced PEPTIC DUODENAL ULCERS and GASTRITIS.

ANTIFUNGAL EFFECT

The use of Lapacho in the treatment of allergic and fungal syndrome dates back to 1983. In subjects with fungal manifestations, it often happens that in the first phase of therapy there is a flare-up of symptoms which then disappear after a certain period of time. This problem is due to the presence of dead cells that spill into the blood circulation causing allergic-type manifestations. From the various studies it was possible to deduce that the subjects who underwent Lapacho therapy gradually became more resistant to chemical agents, food allergies and fungal attacks; there was also a decrease in skin rashes and mycosis on the nails. However, it is important to keep in mind that the healing process is gradual and takes many months. The problem of mycoses, in addition to being linked to people with allergic syndromes, also concerns those people suffering from immunodeficiencies, diabetes mellitus, or people who have undergone treatments with immunosuppressive drugs (antibiotics and glucosteroids) and also women who use the contraceptive pill.

WHY IS LAPACHO RECOMMENDED TO EVERYONE?

Lapacho is used as a preventative during the cold season and whenever the possibility of infection is high. It is one of the best plants for purifying the body, without requiring a large expenditure of energy; in fact it helps to re-stabilise the body's defenses by strengthening the immune system. Lapacho strengthens the immune system and can be recommended to everyone, since with it the liver and lymphatic system reach optimal conditions, without effort and without side effects.

MINERALS CONTAINED IN IT

Lapacho contains a special combination and concentration of quite rare mineral salts or trace elements: calcium, magnesium, phosphorus, zinc, chromium, silicon, manganese, molybdenum, copper, iron, potassium, sodium, cobalt, boron, gold, silver, strontium, barium, nickel.

STOCK OVERVIEW

Respiratory system: fever, cold, sinusitis, flu; gastrointestinal system: dysentery, gastroenteritis; osteoarticular system: arthritis, arthrosis; metabolic alterations: hypercholesterolemia, diabetes; dermatology: acne, fungal diseases, boils, psoriasis, dry eczema, wet eczema, skin ulcers, sun burns; urogenital system: cystitis, candidiasis; cardiovascular system: hemorrhoids.

ANTIOXIDANT EFFECT

In vitro studies have demonstrated definitive inhibition of inflammatory free radicals and leukotrienes through the constituents of Lapacho. This property may be the basis of Lapacho's antiaging effect. Modern science has recently discovered the importance of free radicals in the generation of many debilitating diseases such as ARTHRITIS; among antioxidants, few are as effective as CARNOSOL which is one of the active constituents of Lapacho. Lapacho contains INDOLS which are widely distributed in the Cruciferous family and are known for their cell detoxification activity and promotion of the body's production of the antioxidant GLUTATHIONE.

ANALGESIC EFFECT

The administration of Lapacho is accredited by reports from South American clinics as the primary way to relieve the pain caused by ARTHRITIS.

ANTIBACTERIAL AND ANTIPARASITIC EFFECT

It includes the inhibition and destruction of Gram-positive and acid-strong bacteria (B.subtilis, M.pyogenes aureus). YEASTS, FUNGI, VIRUSES, SEVERAL TYPES OF PARASITES

ANTIBACTERIAL EFFECT

In the 1950s in Brazil (University of Recife) various substances with antibiotic activity were isolated from Lapacho, including Lapacholo which is effective against Gram-positive bacteria (Staphylococcus and Streptococcus; above all it shows a high inhibitory activity against Staphylococcus aureus resistant to penicillin G). Good results have been obtained in the treatment of malaria and against two parasites such as Schistosoma mansoni, which causes bilharzia, a serious tropical disease, and Trypanosoma cruzi responsible for American trypanosomiasis or Chagas disease.

ANTIVIRAL EFFECT

One of the most interesting actions of Lapacho is against viruses. The range of viruses inactivated by Lapacho includes the Herpes simplex virus and those that cause common colds. The antiviral action of Lapacho is mainly due to: Lapachol, HYDROXYNAPHTOQUINONES, QUERCITIN (bioflavonoid) BETA-Lapachone inhibits the enzymes of viral cells which are directly involved in the synthesis of DNA and RNA; it is also a potent inhibitor of the reverse transcriptase enzyme involved in RNA/DNA replication. It therefore acts against retroviruses and against the Epstein-Barr virus (infectious mononucleosis).

ANTI-INFLAMMATORY EFFECT

The anti-inflammatory action of Lapacho has proven useful especially in cases of CERVICITIS and CERVICOVAGINITIS, conditions resulting from various infections (Candida albicans, Trichomonas vaginalis, chemical and mechanical irritations). Lapacho tends to reduce pain in cases of ARTHRITIS. Thanks to Lapacholo, the anti-inflammatory action is perhaps due to an inhibition of inflammatory prostaglandins. Lapacho is useful in case of EDEM, especially in the presence of abscesses.

IMMUNOSTIMULANT EFFECT

The scholar Teodoro Meyer states that liver diseases, IRON DEFICIENCY, ASTHMA, DIABETES, CYSTITIS, RHEUMATISM, prostatitis, become chronic due to poor nutrition associated with the lack of natural defenses. A treatment with Lapacho can be useful in these pathologies. Lapacho induces an acceleration of PHAGOCYTOSIS. Lapacho causes significant stimulation of macrophages whose activity increases as the dose increases.

SIDE EFFECTS

While there is no doubt that Lapacho is highly toxic to many various types of viruses, bacteria, fungi, parasites, and other types of organisms, this substance appears to possess no significant toxicity to healthy human cells. As a precaution, do not take if pregnant or breastfeeding.

Scientific studies published on Lapacho

source: www.elsevier.com

Tabebuia, which currently includes over 100 species, is the most widespread genus of the Bignoniaceae and is found from southwestern America to northern Argentina. Recent molecular studies have shown that Tabebuia is a polyphyletic genus, and that a new taxonomic order has been generated.

The species of Tabebuia characterized by particularly hard wood containing abundant quantities of Lapacho have been included in the genus Handroanthus (Grose and Olmstead, 2007).

Therefore, the new name recently proposed to indicate the new taxonomic arrangements of the Tabebuia Avellanedae is Handroanthus Impetiginosus. However in this study, we will use the name Tabebuia avellanedae, because it is more commonly used in scientific literature. Tabebuia avellanedae, is a species commonly known as "ipe roxo", "Lapacho" and "Taheebo", is used in folk medicine as an anti-inflammatory and in the treatment of ulcers and bacterial and fungal infections (Goel et al., 1987; Schultes and Raffauf, 1990; Miranda et al., 2001).

It has been widely used by the indigenous Tupi-Guarani tribes in South America (Schultes and Raffauf, 1990). The extract from the bark of Tabebuia avellanedae is marketed for the treatment of various pathologies, including gastritis, although there is a lack of studies demonstrating this use.

Some studies have shown that plants of the Tabebuia genus have a broad-spectrum activity as antifungal vectors (Portillo et al., 2001), antibacterial action against Helicobacter Pylori (Park et al., 2006) and Staphylococcus Aureus (Anesini and Perez, 1993), as well as anti-inflammatory (Miranda et al., 2001) and antioxidant activity (Park et al., 2003). The components isolated from Tabebuia species (benzenoids, menadione, Lapachoe and Lapacholo) show many biological activities (Burnett and Thomson, 1967). Menadione has a gastroprotective effect (Tariq and Al Moutaery, 2005).

Lapachone has an anti-inflammatory effect (Moon et al., 2007), inhibits proliferation and induces apoptosis (Sun et al., 2006; Woo et al., 2006; Shah et al., 2007) and has antibacterial and antifungal activity. (Guiraud et al., 1994). Lapacholo has anti-inflammatory (De Almeida et al., 1990) and gastroprotective (Goel et al., 1987), antibacterial and antifungal (Guiraud et al., 1994) actions.

Lapacho is a tree of the Bignoniaceae family commonly known in Brazil as "ipe-roxo". Lapacho bark is used in folk medicine as an analgesic, anti-inflammatory, diuretic, and to treat disorders of the gastrointestinal tract. (Miranda et at., 2001). In the present study, the raw extract from Lapacho bark in ethanol (EET) was studied to verify its action on the gastrointestinal tract.

Oral administration of EET decreased the lesion area favored by ethanol. Nonetheless, this result could be a mechanical effect of the extract on the gastric mucosa, which prevents direct aggression of ethanol in the stomach. Therefore, the effect of intraperitoneal administration of EET in an ethanol-induced injury was investigated. The highest dose tested (300mg/Kg) significantly protected the gastric mucosa against ethanol-induced lesions, allowing us to deduce that the gastroprotective effect of EET does not result from a simple mechanical action.

Ethanol is a well-known necrotizing agent that destroys mucosal protective factors, as well as the mucosal barrier (Wallace, 2001). In this study we observed that the administration of ethanol in rats caused a decrease in the amount of gastric mucus.

Furthermore, the higher dose of EET (i.p.) strengthened the mucous layer of the gastric mucosa, indicating that the maintenance of gastric mucus plays an important role in the gastroprotective effect promoted by the extract. Ibuprofen is an inhibitor of the cyclooxygenases COX-1 and COX-2 (Capone et al., 2007). COXs are constitutively expressed in abundance in the gastrointestinal tract and have been suggested as the factor that maintains mucosal integrity via the continuous generation of prostaglandins (Pgs) (Halter et al., 2001).

A detailed analysis of the protective effect of EET(po) on ibuprofen-induced lesions might suggest that this extract interferes with prostaglandin synthesis.

This hypothesis is supported by our results, which indicate increased gastric mucus protection promoted by EET. Ulceration produced by injection of acetic acid into the gastric wall of rats has been considered similar to chronic ulceration in humans, as it is difficult to treat and requires long healing periods (Takagi et al., 1969). Oral administration of EET for seven consecutive days accelerated the healing process of the gastric mucosa in rats, compared to the control group treated only with the vehicle. This result suggests that Lapacho has effects in the treatment of chronic ulcers.

Another important protective factor is the inhibition of acid secretion (Konturek et al., 2005), since when acid levels exceed the mucosal defense mechanisms, ulcer formation occurs (Schubert, 2004). In our study, EET(id) administration was investigated in the pyloric ligation model, where gastric volume and total acidity were reduced during 4 h of pyloric ligation in rats.

To verify the mechanisms responsible for the anti-secretory action of EET, the sec
Gastric acid ection was stimulated with two factors that promote acid secretion: histamine and bethanechol. Animals that received pretreatment with EET showed inhibition of histamine-stimulated increases in gastric volume and total acidity, but showed no inhibition when challenged with bethanechol.

The proton pump is the main factor responsible for gastric acidity in the stomach, drugs with inhibitory power on this enzyme represent the main pharmacological treatment for peptic ulcers.

We observed that pre-incubation with EET inhibited proton pump activity in vitro, with efficacy comparable to that of omeprazole.

The proton pump is the last step in the production of gastric acid, so it can be deduced that this is the effect of EET responsible for reducing the total gastric acidity produced. Nonetheless, this assumption is incorrect, because total acidity was not reduced by EET pre-treatment when muscarinic receptors were stimulated, whereas it was reduced by EET pre-treatment when H2 receptors were stimulated. Therefore, we believe that the gastric acidity-reducing effect produced by EET concerns not only the inhibition of the proton pump, but also a mechanism controlled by histamine H2 receptors.

In conclusion, the results obtained after oral and intraperitoneal administration of EET suggest that this plant has a protective action against lesions of the gastric mucosa and that this function includes protective factors, such as the strengthening of gastric mucus and interference in the synthesis and degradation of prostaglandins. EET reduced gastric acid secretion by interfering with histamine H2 receptors, or their intracellular signal transduction, and proton pump inhibition.

We confirmed that the gastro-protective action favored by EET is based on multiple mechanisms. These effects are beneficial, because drugs that have a mechanism of action, such as proton pump inhibitors, can generate hypergastrinemia.

A better understanding of the mechanisms and active components present in this plant could, in the future, clarify the scientific basis of its use in folk medicine and also provide new alternatives for the clinical treatment of gastric ulcers.

Note : the information contained in this booklet is not intended to replace the advice of the Doctor, who is responsible for any prescription and therapeutic indication. This information is only an information guide and should absolutely not be disclosed to the public; is reserved only for qualified people in the fields of Medicine and Nutrition

and pharmacy (art.6 paragraph II of DL 111 of 01.27.92).